Hepatoprotective activity of aerial parts of otostegia persica against. Vernonia amygdalina and moringa oleifera are among medicinal plants reported to be used in traditional settings for the management of ailments. Group g and h were administered with 150mgkg and 300 mgkg of vernonia amygdalina respectively for two weeks, before they were injected intraperitonially with 65mgkg of alloxan followed by continuation of 150mgkg and 300mgkg of vernonia amygdalina for another two weeks. The effect of ethanol leaf extract of vernonia amygdalina on some indices of liver, kidney function and lipid profile in male albino wistar rats intoxicated with theobromine was investigated.
Vernonia amygdalina protected against carbon tetrachlorideinduced liver injury by inducing antioxidant and phase 2 enzymes. Request pdf hepatoprotective effects of vernonia amygdalina astereaceae in rats treated with carbon tetrachloride the possible modulatory effect of. The antioxidant activity of vernonia amygdalina has been attributed to the presence of flavonoids, as reported by igile et al. The study investigate the hepatoprotective effect of ethanolic leaf extract of vernonia amygdalina and ethanolic leaf extract of azadirachta indica against acetaminopheninduced hepatotoxicity in sprague dawley. Introduction va is a shrub that can reach 23 feet in height when fully grown echem and kabari, 2012 5. Pdf hepatoprotective and antioxidant activities of vernonia. Uhegbu and ogbuehi 2004 reported the antidiabetic effects of aqueous extract of leaves of vernonia amygdalina. Pdf hepatoprotective effect of methanolic leaf extract of. Neurochemical impact of the aqueous extract of vernonia. It belongs to the family asteraceae, has a rough bark with dense black straits, and elliptic leaves that are about 6 mm in length. Group i was administered with 65mgkg of alloxan and insulin lente 1. The antioxidant, antiinflammatory and analgesic activities of its acetone leaf extract were evaluated in this study to validate its folkloric use. Male albino rats were randomly divided into six groups each consisting of five albino rats.
Effect of methanolic extract of vernonia amygdalina common. Hepatoprotective and antioxidant activities of vernonia amygdalina. Given widespread use of vernonia amygdalina and in the light of the consideration that herdrug interaction is an important safety concern, we provide here the possible effect if any of the extract of the leaves of vernonia amygdalina on the pharmacokinetic profile of. Breast cancer is currently the leading cause of cancerrelated deaths among women globally. Hepatoprotective effect of methanolic leaf extract of.
It is on this premise that this work was designed to evaluate the hypoglycemic, hepatoprotective and. Hypoglycemic, hepatoprotective and nephroprotective effects. Hepatoprotective effect, otostegia persica, liver injury, carbon. Cardiovascular effects of vernonia amygdalina in rats and the. Preparation of methanolic extract of vernonia amygdalina va.
These two studies were conducted separately to collate data on foods in nigeria that will improve glycemic control. Uses, benefits, cures, side effects, nutrients in bitter leaf. Vernonia amygdalina, phytochemical test, ftir spectroscopy, acute toxicity 1. Its effect may range from mild increase in serum liver enzyme activity to. Vernonia amygdalina is traditionally used in ethiopia to treat various diseases. Antioxidant and hepatoprotective effects of solanum. Mar 01, 2010 read hepatoprotective effects of vernonia amygdalina astereaceae in rats treated with carbon tetrachloride, experimental and toxicologic pathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Pdf hepatoprotective and antioxidant activities of. This is so real that in 2004, the world health organization identified it as an epidemic underway, since about 191 million persons world wide were afflicted in 2000 and a possible increase to 366 million by 2030 was projected wild et al. Vernonia amygdalina, commonly called bitter leaf, is a perennial shrub. Vernonia amygdalina is a valuable medicinal plant that is widespread in west africa, it is known as bitter leaf due to its characteristic bitter taste and flavour, and canbe used as an active anticancer, antibacterial, antimalarial and antiparastic agent.
How bitter leaf is effective for various diseases is listed in repertory format. Hepatoprotective effects of berberis vulgaris leaf extract on carbon tetrachlorideinduced hepatotoxicity in rats maryam tahmasebi 1, heibatollah sadeghi 2, habibollah nazem 3, esmaiel panahi kokhdan 2, navid omidifar 4. To evaluate the hepatoprotective properties of otostegia persica o. Acetaminophen paracetamol is a commonly and widely used analgesic and antipyretic agent, but at high dose it leads to undesirable side effects, such as hepatotoxicity. The ability of vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucoseinduced oxidative stress and proinflammation were investigated in rat brain. Hepatoprotective and antioxidant activities of vernonia. Effects of vernonia amygdalina aqueous leaf extract on the. A study on the hepatoprotective effect of vernonia amygdalina leaves ethanolic extract on white rats induced by paracetamol was.
Amygdalin laetrile has not been shown to treat or prevent cancer. Report by atangwho 7 showed vernonia amygdalina to restore the damage previously done to the. Phytochemical and pharmacological prope of vernonia. This study investigated the chemoprotective properties of methanolic extract of vernonia amygdalina meva in an experimental model of hepatic oxidative damage induced by 2acetylaminofluorene 2aaf. Phytochemicals such as saponins and alkaloids, terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, edotides and sesquiterpenes have been extracted and isolated from vernonia amygdalina. However, current research about the mechanisms of the anticancer potential of va. Sep 15, 20 the in vivo micronucleus assay was used to examine the anticlastogenic effects of crude extracts of bridelia ferruginea, vernonia amygdalina, tridax procumbens, ocimum gratissimum, and lawsonia inermis in wistar albino rats. The study investigate the hepatoprotective effect of ethanolic leaf extract of vernonia amygdalina and ethanolic leaf extract of azadirachta indica against acetaminopheninduced hepatotoxicity in sprague dawley male albino rats. Antioxidative and chemopreventive properties of vernonia.
Response from biochemical and toxicity studies in rats the effects of various concentrations of aqueous extract of vernonia amygdalina leaves on some biochemical indices of liver function were investigated in albino wistar rats. Antioxidant and hepatoprotective effects of solanum xanthocarpum leaf extracts against ccl4induced liver injury in rats behrouz jalali ghassam, hadi ghaffari, h. Ethanol leaf extract of vernonia amygdalina has been reported to protect against kidney impairment. The antioxidant activity of vernonia amygdalina has been attributed to. Hepatoprotective effect of methanolic leaf extract of vernonia. The effects of various concentrations of aqueous extract of vernonia amygdalina leaves on some biochemical indices of liver function were investigated in albino wistar rats. However, apart from the differences in the methods of extraction of vernonia amygdalina and the type of andor routes of administration of the hepatotoxicity used. The effect of some of these plant foods like detarium microcarpium legume and vernonia amygdalina vegetable on postprandial glucose response of healthy nondiabetic adults was investigated. The study investigate the hepatoprotective effect of ethanolic leaf extract of vernonia amygdalina and ethanolic leaf extract of azadirachta indica against acetaminopheninduced hepatotoxicity in dawley male albino sprague male albino rats were randomly rats.
Dec 06, 2015 group g and h were administered with 150mgkg and 300 mgkg of vernonia amygdalina respectively for two weeks, before they were injected intraperitonially with 65mgkg of alloxan followed by continuation of 150mgkg and 300mgkg of vernonia amygdalina for another two weeks. Phytochemical analysis of the plant material showed that anthracene glycosides, steroids, flavonoids, proteins, carbohydrates, reducing sugars, saponins and. Read hepatoprotective effects of vernonia amygdalina astereaceae in rats treated with carbon tetrachloride, experimental and toxicologic pathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Phytochemical analysis of vernonia amygdalina and ocimum. Antidiabetic effect of combined aqueous leaf extract of. Antidiabetic effect of combined aqueous leaf extract of vernonia amygdalina and metformin in rats, u adikwu michael, b uzuegbu david, c okoye theophine, f uzor philip, adibe maxwel. Pdf in vitro antioxidant and in vivo hepatoprotective. This prompted us to isolate bioactive compounds from the flowers of this plant.
This plant commonly called as bitter leaf with medium sized shrub and having petiolate green leaf of about 6 mm in diameter akah et al. Pdf effect of aqueous extract of bitter leaf vernonia amygdalina. We have evaluated the hepatoprotective and antioxi dant effects of an aqueous extract of v. Evaluation of the nephroprotective effects of combined. Hepatoprotective effect of ethanolic leaf extract of. These compounds elicit various biological effects including cancer chemoprevention. Hepatoprotective and antioxidant activities of vernonia amygdalina on acetaminopheninduced hepatic damage in mice article pdf available in journal of medicinal food 94.
Family compositae is used in nigerian folk medicine as a tonic and remedy against constipation, fever, high blood pressure, and many infectious diseases. Vernonia amygdalina is well documented to have hepatoprotective effects 10. Notably, medicinal plant extracts may be a potential source for treatments of breast cancer. Vernonia amygdalinaare green with a char acteristic odour and bitter taste. This study was conducted to evaluate the hepatoprotective effect of v. Diabetes control and treatment vernonia amygdalina contains biologicallyactive compounds known as coumarins, flavonoids, anthraquinone, phenolic acids, saponins, sesquiterpenes, xanthones, terpenes, steroids, lignans and edotides. Hepatoprotective and antioxidant activities of vernonia amygdalina on acetaminopheninduced hepatic damage in mice. Albino rats wistar strain were randomly divided into groups of five rats each, group i served as control and was administered normal saline only, group ii were induced 75. Antibacterial and antioxidant compounds from the flower. Lipid lowering effects of bitter leaf vernonia amygdalina in broiler chickens fed finishers mash. In this study, the revealed ameliorative and hepatoprotective effects of meva against. Effect of ethanol leaf extract of vernonia amygdalina on.
Cardiovascular effects of aqueous extract of vernonia amygdalina was investigated in normotensive spraguedawley rats weighing 200250g. Hypoglycemic, hepatoprotective and nephroprotective. Hepatoprotective effects of berberis vulgaris leaf extract on. Studies on the nutritional composition of vernonia amygdalina found its nutritional content to conform to the results obtained for green leafy vegetables. Vernonia amygdalina, commonly known as bitter leaf, is a shrub that. We have evaluated the hepatoprotective and antioxidant effects of an aqueous extract of v. This study investigated the hepatoprotective effect of methanolic leaf extract of vernonia amygdalina against acetaminopheninduced hepatotoxicity in wistar albino rats. Vernonia amygdalina has been a known food and medicinal plants used in asia and. Vernonia amygdalina has been a known food and medicinal plants used in asia and africa west africa due to its pharmacological effects antioxidant, antidiabetes, antiinflammatory, anticancer, antimalaria, and among others. Due to its numerous medicinal benefits, the leaf of vernonia amygdalina has found wide application in. It can be broken down by enzymes in the intestine to produce cyanide, a known poison. The effects of vernonia amygdalina leaves on lipid profile in. Effect of ethanol leaf extract of vernonia amygdalina on some.
Eight hundred twenty gram of sundried and pulverized roots of va was immersed in 5 l of methanol for five days to ensure sufficient extraction of the active components. Introduction vernonia amygdalina, commonly called bitter leaf, is a perennial shrub of 25m in height that grows throughout tropical africa. Thirty 30 male wistar rats weighing between 140 g 160 g used for the study were divided into 6. Intravenous femoral vein administration of the extract at doses of 5. Philipson et al, 1993 reported the antiplasmodial effects of sesquiterpene and steroidal constituents of v.
Hepatoprotective effects of vernonia amygdalina astereaceae in rats treated with carbon tetrachloride. Issn 23203862 phytochemicals and acute oral toxicity. Effect of aqueous extract of bitter leaf vernonia amygdalina. Vernonia amygdalina del extract has a very promising hepatoprotective potential against. The present study equally revealed the hypoglycemic properties of vernonia amygdalina and talinum triangulare, the current findings are in line with previous study which showed that vernonia amygdalina has hepatoprotective and hypoglycemic effect 24, coupled with the fact that the aqueous extract of.
Acute toxicity tests of the extract gave an ld50 of 500 mgkg. Cardiovascular effects of vernonia amygdalina in rats and. Hepatoprotective potential of some local medicinal plants. The effects of various concentrations of ethanolic extracts of vernonia amygdalina va stem and root on some biochemical indices of liver function in streptozotocininduced diabetic and nondiabetic rats treated with 200mgkg b. Effect of vernonia amygdalina del leaf on kidney function of. The in vivo micronucleus assay was used to examine the anticlastogenic effects of crude extracts of bridelia ferruginea, vernonia amygdalina, tridax procumbens, ocimum gratissimum, and lawsonia inermis in wistar albino rats. Cytoprotective effects of ethanolic extract of vernonium. Hepatoprotective effects of vernonia amygdalina astereaceae. Natural products possessing antioxidant properties play a very crucial role in ameliorating deleterious effects of reactive oxygen species. The hepatoprotective effect of aqueous extract of vernonia amygdalina on acetaminopheninduced liver damage in abino. Hepatoprotective effect of ethanolic leaf extract of vernonia. Names of bitter leaf in various languages of the world are also given. The antioxidant, antidiabetic, hepatoprotective, haematological, antiplasmodial, antimicrobial, anticancer, antiinflammatory, pharmacological and medicinal value of vernonia amygdalina is no.
Vernonia amygdalina is a medicinal plant of great importance that has its fresh leaves rich in vitamins and salt hence, it is valuable in human diet. Using spectroscopic techniques, the study had isolated and. The present study equally revealed the hypoglycemic properties of vernonia amygdalina and talinum triangulare, the current findings are in line with previous study which showed that vernonia amygdalina has hepatoprotective and hypoglycemic effect 24, coupled with the fact that the aqueous extract of vernonia has. Africa west africa due to its pharmacological effects antioxidant. The phytochemical studies revealed that this plant is enriched with proteins, fats, fibres, amino acids, minerals.
Prakash, and kukkundoor ramachandra kini pharmaceutical biology downloaded from by mcmaster university on 101614 for personal use only. Diabetes mellitus remains one of the agelong chronic diseases of the human race and its frontiers are expanding by the day. The possible modulatory effect of methanolic extract of vernonia amygdalina meva, a plant widely consumed in the tropics and used locally in the treatment of fever, jaundice, stomach disorders and diabetes on the toxicity of ccl 4, was investigated in male rats. Bitter leaf herb uses, benefits, cures, side effects, nutrients. The anticancer activities of vernonia amygdalina extract in. Hepatoprotective effects of vernonia amygdalina astereaceae in. Hepatoprotective effects of vernonia amygdalina astereaceae in rats treated.